/* Clinical Research Insights frontend layout. No external frameworks required. */
.cri-site{margin:0;background:#f6f8f8;color:#16323d;font-family:Inter,"Segoe UI",Arial,sans-serif;line-height:1.6}
.cri-site *, .cri-site *:before, .cri-site *:after{box-sizing:border-box}
.cri-site a{color:inherit}
.cri-site a:focus-visible,.cri-site button:focus-visible,.cri-site input:focus-visible{outline:3px solid #65ccaf;outline-offset:3px}
.cri-container{width:min(100% - 48px,1350px);margin:0 auto}
.cri-skip{position:absolute;top:-80px;left:15px;z-index:20;background:#dcf8db;padding:9px 16px}
.cri-skip:focus{top:10px}
.cri-sitebar{position:relative;background:#071f2a;color:#fff;border-bottom:1px solid #34525c}
.cri-sitebar-inner{display:flex;gap:21px;align-items:center;min-height:68px;width:min(100% - 48px,1350px);margin:0 auto}
.cri-sitebar a{text-decoration:none}
.cri-brand{font-size:18px;font-weight:850;letter-spacing:-.045em;color:#f0fff5}
.cri-sitebar-divider{width:1px;background:#44606a;height:23px}
.cri-product-link{font-size:13px;font-weight:750;color:#c9eedb}
.cri-sitebar-caption{margin-left:auto;font-size:11px;letter-spacing:.11em;text-transform:uppercase;color:#abc3c4;font-weight:700}
.cri-eyebrow-public{text-transform:uppercase;font-size:11px;letter-spacing:.16em;font-weight:780;color:#167d71;display:flex;align-items:center;gap:10px}
.cri-live-dot{width:8px;height:8px;background:#d7f59d;border-radius:100%;display:inline-block}
.cri-index-hero{background:radial-gradient(circle at 95% 30%,rgba(60,120,111,.19),transparent 34%),linear-gradient(125deg,#06212c,#0e333d 63%,#114642);color:#fff;position:relative;overflow:hidden}
.cri-index-hero:after{content:"";border:1px solid #7da79e30;border-radius:50%;height:650px;width:650px;position:absolute;right:-410px;top:-220px;pointer-events:none}
.cri-index-hero .cri-container{padding:78px 0 72px;position:relative;z-index:1}
.cri-index-hero .cri-eyebrow-public{color:#ccefc9;margin-bottom:27px}
.cri-index-hero-layout{display:grid;grid-template-columns:minmax(0,1fr) 250px;gap:50px;align-items:center}
.cri-index-hero h1{font:normal clamp(44px,5vw,77px)/1.04 Georgia,serif;letter-spacing:-.055em;margin:0 0 27px;max-width:850px}
.cri-index-hero h1 em{color:#dcf5a2;font-weight:normal;font-style:italic}
.cri-index-intro{font-size:clamp(16px,1.4vw,20px);color:#bed6d8;max-width:710px;line-height:1.65;margin:0}
.cri-index-stat{border:1px solid #64858370;background:#1a474a9c;border-radius:14px;padding:25px;display:flex;flex-direction:column;gap:13px;max-width:260px}
.cri-index-stat span,.cri-index-stat small{font-size:11px;color:#c1ded5;line-height:1.5}
.cri-index-stat strong{font-size:70px;color:#dff8ad;letter-spacing:-.07em;line-height:1}
.cri-search-form{background:#fff;color:#16343b;margin-top:48px;padding:21px 23px;border:1px solid #cee0dc;border-radius:12px;max-width:1020px;box-shadow:0 26px 80px #0002}
.cri-search-form label{font-size:11px;text-transform:uppercase;font-weight:800;letter-spacing:.12em;display:block;margin-bottom:10px;color:#44736e}
.cri-search-row{display:flex;gap:10px}
.cri-search-row input{background:#f5f9f8;border:1px solid #d6e1df;border-radius:8px;font:inherit;color:#16333c;padding:14px 17px;width:100%;min-width:0;flex:1}
.cri-search-row button{border:0;border-radius:8px;background:#106f63;color:white;padding:14px 21px;font:inherit;font-size:13px;font-weight:760;cursor:pointer;white-space:nowrap}
.cri-search-row button:hover{background:#07534c}
.cri-index-body{padding-top:76px;padding-bottom:105px}
.cri-results-heading{display:flex;align-items:end;justify-content:space-between;gap:18px;border-bottom:1px solid #cfdcdd;padding-bottom:23px;margin-bottom:30px}
.cri-results-heading h2,.cri-after-heading h2{font:normal clamp(33px,3vw,45px)/1.2 Georgia,serif;letter-spacing:-.05em;margin:10px 0 0}
.cri-result-count{color:#607980;font-size:12px;font-weight:700}
.cri-search-term{font-size:13px;color:#58757d;margin:0 0 25px}
.cri-search-term a{color:#0d756a;font-weight:700}
.cri-article-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:19px}
.cri-article-card{border:1px solid #d7e3e5;background:#fff;min-height:350px;padding:28px 28px 23px;border-radius:13px;display:flex;flex-direction:column;transition:transform .18s ease,box-shadow .18s ease,border-color .18s ease;box-shadow:0 4px 12px #06272a08}
.cri-article-card:hover{transform:translateY(-4px);box-shadow:0 18px 45px #0a3f3c18;border-color:#96cabb}
.cri-card-upper{display:flex;align-items:center;justify-content:space-between;margin-bottom:20px}
.cri-card-category{display:flex;align-items:center;gap:12px;text-transform:uppercase;font-size:10px;letter-spacing:.07em;color:#36766c;font-weight:800}
.cri-card-index{background:#e5f1ed;color:#157468;border-radius:100px;padding:4px 8px;font-weight:850}
.cri-card-arrow{border:1px solid #c6d8d8;border-radius:100px;height:35px;width:35px;text-decoration:none;display:grid;place-items:center;font-size:19px;color:#066b60}
.cri-article-card h3{font:normal 24px/1.26 Georgia,serif;letter-spacing:-.035em;margin:0 0 18px;color:#19343c}
.cri-article-card h3 a{text-decoration:none}
.cri-article-card h3 a:hover{text-decoration:underline;text-decoration-color:#9ccbb8;text-underline-offset:5px}
.cri-article-card>p{color:#668089;font-size:13px;line-height:1.77;margin:0 0 29px;display:-webkit-box;-webkit-box-orient:vertical;-webkit-line-clamp:4;overflow:hidden}
.cri-card-bottom{border-top:1px solid #e3ecea;margin-top:auto;padding-top:18px;display:flex;justify-content:space-between;align-items:center;gap:10px;font-size:11px}
.cri-card-bottom span{color:#758e91}
.cri-card-bottom a{color:#0b7469;text-decoration:none;font-weight:800}
.cri-empty-state{background:white;border:1px dashed #bad1cc;border-radius:16px;padding:66px 30px;text-align:center}
.cri-empty-state>span{font-size:49px;color:#14736d}
.cri-empty-state h3{font:normal 29px Georgia,serif;margin:8px 0 5px}
.cri-empty-state p{font-size:14px;color:#6a828b}
.cri-pagination{display:flex;gap:8px;margin-top:39px}
.cri-pagination a{border:1px solid #d2e0db;border-radius:8px;padding:9px 14px;text-decoration:none;font-size:13px;font-weight:750;color:#2d6661;background:white}
.cri-pagination a.active{background:#0d665e;color:#fff;border-color:#0d665e}
.cri-detail-page{padding-top:21px}
.cri-breadcrumb-line{display:flex;justify-content:space-between;gap:15px;align-items:center;margin-bottom:19px}
.cri-breadcrumb{display:flex;align-items:center;gap:12px;flex-wrap:wrap;color:#73878d;font-size:11px}
.cri-breadcrumb a{text-decoration:none;color:#1e766c;font-weight:780}
.cri-draft-banner{color:#835000;border-radius:6px;background:#fdf0c6;padding:8px 12px;font-size:11px;letter-spacing:.06em}
.cri-article-host{width:min(100% - 48px,1440px);margin:0 auto;background:#fff;box-shadow:0 16px 55px #0a3f4210;border:1px solid #e1e9e8;border-radius:12px;overflow:hidden}
/* The article itself is stored unchanged, but the first hero H2 becomes H1 at render time for semantics. */
.cri-article-host .cri-article .cri-hero h1{color:#fff;font-family:Georgia,"Times New Roman",serif;font-size:clamp(35px,5.3cqw,66px);line-height:1.06;max-width:790px;margin:0 0 24px;letter-spacing:-.045em;font-weight:normal}
.cri-after-article{padding-top:78px;padding-bottom:85px}
.cri-after-inner{border-top:1px solid #cadbd8;padding-top:40px}
.cri-after-heading{margin-bottom:28px}
.cri-related-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px}
.cri-related-card{border:1px solid #d7e1df;background:#fff;border-radius:11px;padding:22px;text-decoration:none;display:flex;flex-direction:column;gap:18px;min-height:185px}
.cri-related-card>span{font-size:9px;letter-spacing:.1em;color:#347b71;font-weight:850}
.cri-related-card strong{font:normal 22px/1.25 Georgia,serif;color:#213d44}
.cri-related-card em{font-style:normal;font-size:12px;color:#0c776a;font-weight:780;margin-top:auto}
.cri-return{display:inline-block;margin-top:26px;color:#0b776b;text-decoration:none;font-size:13px;font-weight:800}
.cri-muted{color:#6f8284;font-size:14px}
.cri-sitefoot{border-top:1px solid #36515a;background:#08232e;color:#c5d9d5}
.cri-sitefoot-inner{width:min(100% - 48px,1350px);margin:0 auto;padding:26px 0 33px;display:flex;align-items:start;justify-content:space-between;gap:30px}
.cri-sitefoot-inner>div{font-weight:800;color:#e4f7ef;font-size:14px}
.cri-sitefoot-inner div span{color:#77c7a0;margin:0 8px}
.cri-sitefoot-inner>p{font-size:11px;max-width:500px;text-align:right;margin:0;line-height:1.7}
@media(max-width:1060px){.cri-article-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.cri-related-grid{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media(max-width:720px){.cri-container{width:min(100% - 32px,1350px)}.cri-sitebar-inner,.cri-sitefoot-inner{width:min(100% - 32px,1350px)}.cri-sitebar-inner{min-height:60px;gap:12px}.cri-brand{font-size:16px}.cri-product-link{font-size:11px}.cri-sitebar-caption{display:none}.cri-index-hero .cri-container{padding:55px 0 56px}.cri-index-hero-layout{grid-template-columns:minmax(0,1fr);gap:28px}.cri-index-hero h1{font-size:clamp(42px,9vw,58px)}.cri-index-stat{max-width:none;padding:13px 17px;gap:6px}.cri-index-stat strong{font-size:40px}.cri-search-form{margin-top:28px;padding:16px}.cri-search-row{flex-direction:column}.cri-index-body{padding-top:52px;padding-bottom:60px}.cri-results-heading h2{font-size:31px}.cri-article-grid{grid-template-columns:1fr}.cri-article-card{min-height:290px;padding:24px}.cri-related-grid{grid-template-columns:1fr}.cri-article-host{width:min(100% - 16px,1440px)}.cri-breadcrumb-line{width:min(100% - 24px,1350px);align-items:flex-start;flex-direction:column}.cri-after-article{padding-top:52px;padding-bottom:60px}.cri-sitefoot-inner{flex-direction:column;gap:12px}.cri-sitefoot-inner>p{text-align:left}}
@media(prefers-reduced-motion:reduce){.cri-article-card{transition:none}}